Human breast fibrocystic change. Light micrograph of three lactiferous ducts and a lobule isolated in a fibrous connective tissue stroma. The increase of fibrous tissue manifests as a lumpy, cobblestone texture in the breasts. Breast fibrocystic change is a general term to describe a range of common and benign breast conditions, such as adenosis, fibrosis and cyst formation, which may occur together or in isolation.