Illustration of the transient receptor potential cation channel, subfamily M, member 7 (TRPM7) in its open (top left) and closed (top right) configurations and in a cell membrane (centre). TRPM7 regulates the uptake of divalent cations, such as calcium and magnesium into a cell. It plays an essential role in embryonic development, immune response, cell mobility, proliferation, and differentiation. TRPM7 is implicated in neuronal and cardiovascular disorders, tumour progression and has emerged as a new drug target.