The cerebellum of a mouse is shown here in cross section. The cerebellum is the locomotion control center of the brain. Every time you shoot a basketball, tie your shoe, or chop an onion, your cerebellum springs into action. Located at the base of your brain, the cerebellum is a single layer of tissue with deep folds like an accordion. People with damage to this area of the brain often have difficulty with balance, coordination, and fine motor skills.