Molecular model of prokaryotic GLIC synaptic receptor (Gloeobacter Ligand-gated Ion Channel, blue and purple) complexed with omega-3 fatty acid docosahexaenoic acid (DHA, yellow spheres) molecules. When a neurotransmitter binds to a channel, GLICs allow for ions to pass through a channel. However, when DHA binds to GLIC, it conforms the ion channel into a desensitised state. Desensitization occurs when an ion channel tends to close despite a neurotransmitter being bound to it. In this case, desensitization occurs because the DHA molecule binds to a site at the edge of the channel causing a change in the structure of GLIC. This leaves the upper part of the channel open while the lower part is constricted and closed, enhancing channel desensitization. Understanding channel desensitization, could allow development of drugs that target desensitized ion channels.

px px dpi = cm x cm = MB
Details

Creative#:

TOP26538048

Source:

達志影像

Authorization Type:

RM

Release Information:

須由TPG 完整授權

Model Release:

N/A

Property Release:

N/A

Right to Privacy:

No

Same folder images:

Same folder images