Uric acid production of hepatocytes, joint inflammation, urolithiasis, treatments. At the top, production of endogenous purine bases at the level of the liver and exogenous by the food (gut). hepatocytes convert purine bases into uric acid eliminated by the kidneys. In case of excess, under the effect of hyperuricemia, sodium urate crystallizes and is deposited in tissues such as joints. Deposits disintegrate. The resulting inflammatory reaction causes the gout crisis.