Site of action of drugs in the treatment of acute otitis media. Frontal cut of the auditory apparatus passing through the outer ear and the middle ear with a purulent effusion in the middle ear and inflammation of the mucous membrane. Below, zoom on the mucosa with a Haemophilus influenzae bacterium seen in section allowing to see the different layers of the wall with the betalactamases of the periplasmic space and the PLP of the cytoplasmic membrane bacterial DNA with the ribosomes.