Binswanger's disease. Coloured axial computed tomography (CT) scan of the brain of a 57-year-old patient with Binswanger's disease. The front of the brain is at top in this view from below. The progression of this degenerative disease has caused atrophy in both halves of the brain, seen as the abnormal gaps appearing in the brain tissue. The ventricles (centre, black) have also been affected and are dilated from their normal size. The disease, also called Binswanger's dementia, involves disruption of the brain's blood supply, which starves areas of the brain of oxygen, resulting in the death of nerve cells. Symptoms include depression, muscle rigidity, difficulties walking and urinary incontinence. There is no cure for the condition.