Diabetes could not be controlled until insulin was found. It was Frederick Grant Banting (1891-1941), and Charles Herbert Best (1899-1978), working under the direction of J.J.R. Macleod, who in 1921 isolated a hormone from the pancreas that would later be called insulin. Banting and Best are shown here on the roof of the medical building at the University of Toronto with one of the first diabetic dogs to have been saved by insulin.